| Rank | Name | Height ft / m |
Floors | Year | Notes |
|---|---|---|---|---|---|
| 1 | 100 North Main | 430 / 131 | 37 | 1965 | Tallest building in Memphis. |
| 2 | Morgan Keegan Tower | 403 / 123 | 21 | 1985 | Includes the spire atop the building |
| 3 | Clark Tower | 403 / 122 | 34 | 1971 | Tallest building outside of downtown. |
| 4 | One Commerce Square | 396 / 121 | 31 | 1973 | |
| 5 | Sterick Building | 365 / 111 | 29 | 1930 | Was the tallest building in Memphis from 1930-1965. |
| 6 | First Tennessee Bank Building | 332 / 101 | 25 | 1964 | |
| 7 | Hilton Memphis | 329 / 100 | 27 | 1975 | Tallest hotel in Memphis. |
| 8 | Pyramid Arena | 321 / 98 | 1991 | ||
| 9 | Renaissance Apartments | 296 / 90 | 25 | 1968 | |
| 10 | Lincoln American Tower | 290 / 88 | 22 | 1924 | |
| 11 | White Station Tower | 274 / 85.5 | 22 | 1965 | Located outside of downtown Memphis in East Memphis. |
| 12 | Exchange Building | 264 / 80.5 | 19 | 1910 | Former site of Memphis Cotton Exchange |
| 13 | Madison Hotel | 200 / 66.75 | 16 | 1905 |